Study of Michael addition on chalcones and or chalcone analogues
نویسندگان
چکیده
منابع مشابه
Kinetic Analysis of Some Chalcones and Synthetic Chalcone Analogues on the Fenton-Reaction Initiated Deoxyribose Degradation Assay1
Investigation of in vitro hydroxyl radical scavenging (antioxidant) effect 4-methoxychalcone (1a) and its cyclic analogues (2a-4a), as well as their hydroxyl substituted counterparts (1b-4b) was performed by means of the Fenton-reaction initiated deoxyribose degradation assay in short term (10 minute) and long term (240 minute) experiments. The kinetic deoxyribose method provides possibility to...
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The catalytic asymmetric aza-Michael reaction of benzoyl hydrazine toward chalcones through the nonactivated amine moiety conjugated addition was facilitated by the developed N,N'-dioxide-Sc(OTf)(3) complex under mild conditions, affording the pharmacologically and synthetically useful products in moderate to high yields with up to 97% ee.
متن کاملHighly enantioselective Michael addition of cyclopentanone with chalcones via novel di-iminium mechanism.
The highly efficient asymmetric Michael addition reactions of cyclopentanone with chalcones were catalyzed by a simple and commercially available chiral 1,2-diaminocyclohexane-hexanedioic acid, and exhibited good yields (up to 92%) and excellent enantioselectivities (up to 99% ee). A new di-iminium mechanism for the reaction was proposed.
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Interaction of the synthetic chalcones (1b,1c) and their cyclic analogues (2b,2c) with bovine (BSA) and human serum albumin (HSA) as well as with rat liver mitochondria (RLM) was studied by fluorescence spectroscopy. The maxima of emission fluorescence spectra were changed only in the case of 2b and 2c during interaction with BSA, HSA as well as mitochondrial outer membrane showing a slight hyp...
متن کامل-Fluoro- -nitro(phenylsulfonyl)methane as a fluoromethyl pronucleophile: Efficient stereoselective Michael addition to chalcones
Highly efficient stereoselective 1,4-addition of racemic -fluoronitro(phenylsulfonyl)methane (FNSM) as a fluoromethyl pronucleophile to , -unsaturated ketones using a wide range of chiral organobifunctional catalysts under moderate conditions in the absence of an additional base has been achieved. A series of catalysts was screened for the enantioselective addition of FNSM to chalcones and the ...
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ژورنال
عنوان ژورنال: Journal of Saudi Chemical Society
سال: 2012
ISSN: 1319-6103
DOI: 10.1016/j.jscs.2010.10.017